Skincare · Treatment
Differin Adapalene Gel 0.1%
Adapalene is a retinoid with solid clinical evidence for treating acne and improving skin texture. This is one of the strongest OTC options available.
✓ Pros
- Strong clinical evidence for acne
- Also helps with texture and signs of aging
- More stable and less irritating than some retinols
- Available without a prescription
- Once-daily use is enough for most people
✗ Cons
- Can cause dryness, peeling or irritation at first
- Must be used with sunscreen every day
- Results take several weeks
- Not ideal for very sensitive skin without gradual introduction
Our Review
Differin (adapalene 0.1%) is one of the most evidence-backed skincare products you can buy over the counter. It is a true retinoid, not just a cosmetic retinol, and has been studied extensively for acne.
Start slowly (every other night or 2–3 times per week), use a good moisturizer, and always apply sunscreen during the day. Consistency is more important than high frequency at the beginning.